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Global Self-replicating mRNA Vaccines Market Outlook, In‑Depth Analysis & Forecast to 2031
Published Date: October 2025
|
Report Code: QYRE-Auto-26F17214
Home | Market Reports | Science| Biological Sciences
Global Self replicating mRNA Vaccines Market Research Report 2024
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Global Self-replicating mRNA Vaccines Market Outlook, In‑Depth Analysis & Forecast to 2031

Code: QYRE-Auto-26F17214
Report
October 2025
Pages:169
QYResearch
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DESCRIPTION
TABLE OF CONTENT
TABLES & FIGURES
FEATURED COMPANIES
Chimeron Bio
Ziphius Vaccines
Aldevron
VaxEquity
Precision Nanosystems
Replicate Bioscience
Elixirgen Therapeutics
Immorna
CSL Limited
Arcturus Therapeutics
BioNTech
GSK
Gritstone Bio

Self-replicating mRNA Vaccines Market

The global Self-replicating mRNA Vaccines market is projected to grow from US$ million in 2024 to US$ million by 2031, at a CAGR of %(2025-2031), driven by critical product segments and diverse end‑use applications, while evolving U.S. tariff policies introduce trade‑cost volatility and supply‑chain uncertainty.
A more common name for self-replicating mRNA is self-amplifying RNA (saRNA). The important difference compared to ordinary mRNA is that it can use its own RNA sequence as a template to replicate itself. Usually mRNA encodes the protein that needs to be expressed, and the ribosomes in the cell are used to complete the translation and protein production. In addition to expressing the target protein, saRNA also carries a sequence that can express RNA polymerase (RNA-dependent RNA polymerase, RdRP). After this RNA polymerase is produced, it can use saRNA as a template to produce more copies of saRNA.
From a downstream perspective, Infectious Disease accounted for % of 2024 revenue, surging to US$ million by 2031 (CAGR: % from 2025–2031).
Self-replicating mRNA Vaccines leading manufacturers including Chimeron Bio, Ziphius Vaccines, Aldevron, VaxEquity, Precision Nanosystems, Replicate Bioscience, Elixirgen Therapeutics, Immorna, CSL, Arcturus Therapeutics, etc., dominate supply; the top five capture approximately % of global revenue, with Chimeron Bio leading 2024 sales at US$ million.
Regional Outlook:
North America rose from US$ million in 2024 to a forecast US$ million by 2031 (CAGR %).
Asia‑Pacific will expand from US$ million to US$ million (CAGR  %), led by China (US$ million in 2024, % share rising to % by 2031), Japan (CAGR %), South Korea (CAGR %), and Southeast Asia (CAGR %).
Europe is set to grow from US$ million to US$ million (CAGR %), with Germany projected to hit US$ million by 2031 (CAGR %).

Report Includes:

This definitive report equips CEOs, marketing directors, and investors with a 360° view of the global Self-replicating mRNA Vaccines market, seamlessly integrating production and sales performance across the value chain. It analyzes historical sales volume and revenue sales data (2020–2024) and delivers forecasts through 2031, illuminating demand trends and growth drivers.
By segmenting the market by Type and by Application, the study quantifies volume and value, growth rates, technical innovations, niche opportunities, and substitution risks, and analyzes downstream customers distribution pattern.
Granular regional insights cover five major markets—North America, Europe, APAC, South America, and MEA—with in‑depth analysis of 20+ countries. Each region’s dominant products, competitive landscape, and downstream demand trends are clearly detailed.
Critical competitive intelligence profiles manufacturers—sales volume, revenue, margins, pricing strategies, and major customers—and dissects the top-player positioning across product lines, applications, and regions to reveal strategic strengths.
A concise supply‑chain overview maps upstream suppliers, manufacturing technologies, cost structures, and distribution dynamics to identify strategic gaps and unmet demand.
Market Segmentation

Scope of Self-replicating mRNA Vaccines Market Report

Report Metric Details
Report Name Self-replicating mRNA Vaccines Market
Segment by Type
  • Preventive Medicine
  • Medicine
Segment by Application
  • Infectious Disease
  • Cancer
  • Others
Sales by Region
  • North America (United States, Canada)
  • Europe (Germany, France, UK, Italy, Russia) Rest of Europe
  • Nordic Countries
  • Asia-Pacific (China, Japan, South Korea)
  • Southeast Asia (India, Australia)
  • Rest of Asia
  • Latin America (Mexico, Brazil)
  • Rest of Latin America
  • Middle East & Africa (Turkey, Saudi Arabia, UAE, Rest of MEA)
By Company Chimeron Bio, Ziphius Vaccines, Aldevron, VaxEquity, Precision Nanosystems, Replicate Bioscience, Elixirgen Therapeutics, Immorna, CSL, Arcturus Therapeutics, BioNTech, GSK, Gritstone Bio
Forecast units USD million in value
Report coverage Revenue and volume forecast, company share, competitive landscape, growth factors and trends

Chapter Outline

  • Chapter 1: Defines the Self-replicating mRNA Vaccines study scope, segments the market by Type and by Application, etc, highlights segment size and growth potential.
  • Chapter 2: Offers current market state, projects global revenue and sales to 2031, pinpointing high consumption regions and emerging market catalysts
  • Chapter 3: Dissects the manufacturer landscape—ranks by volume and revenue, analyzes profitability and pricing, maps production bases, details manufacturer performance by product type and evaluates concentration alongside M&A moves.
  • Chapter 4: Unlocks high margin product segments—compares sales, revenue, ASP, and technology differentiators, highlighting growth niches and substitution risks
  • Chapter 5: Targets downstream market opportunities—evaluates sales, revenue, and pricing by Application, identifies emerging use cases, and profiles leading customers by region and by Application.
  • Chapter 6: North America—breaks down sales and revenue by Type, by Application and country, profiles key manufacturers and assesses growth drivers and barriers.
  • Chapter 7: Europe—analyses regional sales, revenue and market by Type, by Application and manufacturers, flagging drivers and barriers.
  • Chapter 8: Asia Pacific—quantifies sales and revenue by Type, by Application, and region/country, profiles top manufacturers, and uncovers high potential expansion areas.
  • Chapter 9: Central & South America—measures sales and revenue by Type, by Application, and country, profiles top manufacturers, and identifies investment opportunities and challenges.
  • Chapter 10: Middle East and Africa—evaluates sales and revenue by Type, by Application, and country, profiles key manufacturers, and outlines investment prospects and market hurdles
  • Chapter 11: Profiles manufacturers in depth—details product specs, sales, revenue, margins; Top manufactures 2024 sales breakdowns by Product type, by Application, by sales region SWOT analysis, and recent strategic developments.
  • Chapter 12: Supply chain—analyses upstream raw materials and suppliers, manufacturing footprint, regional production and cost, regulatory and technology, plus downstream channels and distributor roles.
  • Chapter 13: Market dynamics—explores drivers, restraints, regulatory impacts, and risk mitigation strategies.
  • Chapter 15: Actionable conclusions and strategic recommendations.
  • Why This Report:
  • Beyond standard market data, this analysis provides a clear profitability roadmap—empowering you to:
  • Allocate capital strategically to high growth regions (Chapters 6–10) and margin rich segments (Chapter 5).
  • Negotiate from strength with suppliers (Chapter 12) and customers (Chapter5) using cost and demand intelligence.
  • Outmaneuver competitors with granular insights into their operations, margins, and strategies (Chapters 3 and 11).
  • Secure your supply chain against disruptions through upstream and downstream visibility (Chapters 12 and 13).
  • Leverage this 360° intelligence to turn market complexity into actionable competitive advantage.

FAQ for this report

Who are the main players in the Self-replicating mRNA Vaccines Market report?

Ans: The main players in the Self-replicating mRNA Vaccines Market are Chimeron Bio, Ziphius Vaccines, Aldevron, VaxEquity, Precision Nanosystems, Replicate Bioscience, Elixirgen Therapeutics, Immorna, CSL, Arcturus Therapeutics, BioNTech, GSK, Gritstone Bio

What are the Application segmentation covered in the Self-replicating mRNA Vaccines Market report?

Ans: The Applications covered in the Self-replicating mRNA Vaccines Market report are Infectious Disease, Cancer, Others

What are the Type segmentation covered in the Self-replicating mRNA Vaccines Market report?

Ans: The Types covered in the Self-replicating mRNA Vaccines Market report are Preventive Medicine, Medicine

1 Study Coverage
1.1 Introduction to Self-replicating mRNA Vaccines: Definition, Properties, and Key Attributes
1.2 Market Segmentation by Type
1.2.1 Global Self-replicating mRNA Vaccines Market Size by Type, 2020 VS 2024 VS 2031
1.2.2 Preventive Medicine
1.2.3 Medicine
1.3 Market Segmentation by Application
1.3.1 Global Self-replicating mRNA Vaccines Market Size by Application, 2020 VS 2024 VS 2031
1.3.2 Infectious Disease
1.3.3 Cancer
1.3.4 Others
1.4 Assumptions and Limitations
1.5 Study Objectives
1.6 Years Considered
2 Executive Summary
2.1 Global Self-replicating mRNA Vaccines Revenue Estimates and Forecasts 2020-2031
2.2 Global Self-replicating mRNA Vaccines Revenue by Region
2.2.1 Revenue Comparison: 2020 VS 2024 VS 2031
2.2.2 Historical and Forecasted Revenue by Region (2020--2031)
2.2.3 Global Revenue Market Share by Region (2020-2031)
2.3 Global Self-replicating mRNA Vaccines Sales Estimates and Forecasts 2020-2031
2.4 Global Self-replicating mRNA Vaccines Sales by Region
2.4.1 Sales Comparison: 2020 VS 2024 VS 2031
2.4.2 Historical and Forecasted Sales by Region (2020-2031)
2.4.3 Emerging Market Focus: Growth Drivers & Investment Trends
2.4.4 Global Sales Market Share by Region (2020-2031)
3 Competition by Manufacturers
3.1 Global Self-replicating mRNA Vaccines Sales by Manufacturers
3.1.1 Global Sales Volume by Manufacturers (2020-2025)
3.1.2 Global Top 5 and Top 10 Manufacturers’Market Share by Sales Volume (2024)
3.2 Global Self-replicating mRNA Vaccines Manufacturer Revenue Rankings and Tiers
3.2.1 Global Revenue (Value) by Manufacturers (2020-2025)
3.2.2 Global Key Manufacturer Revenue Ranking (2023 vs. 2024)
3.2.3 Revenue-Based Tier Segmentation (Tier 1, Tier 2, and Tier 3)
3.3 Manufacturer Profitability Profiles and Pricing Strategies
3.3.1 Gross Margin by Top Manufacturer (2020 VS 2024)
3.3.2 Manufacturer-Level Price Trends (2020-2025)
3.4 Key Manufacturers Manufacturing Base and Headquarters
3.5 Main Product Type Market Size by Manufacturers
3.5.1 Preventive Medicine Market Size by Manufacturers
3.5.2 Medicine Market Size by Manufacturers
3.6 Global Self-replicating mRNA Vaccines Market Concentration and Dynamics
3.6.1 Global Market Concentration (CR5 and HHI)
3.6.2 Entrant/Exit Impact Analysis
3.6.3 Strategic Moves: M&A, Capacity Expansion, R&D Investment
4 Global Product Segmentation Analysis
4.1 Global Self-replicating mRNA Vaccines Sales Performance by Type
4.1.1 Global Historical and Forecasted Sales by Type (2020-2031)
4.1.2 Global Sales Market Share by Type (2020-2031)
4.2 Global Self-replicating mRNA Vaccines Revenue Trends by Type
4.2.1 Global Historical and Forecasted Revenue by Type (2020-2031)
4.2.2 Global Revenue Market Share by Type (2020-2031)
4.3 Global Average Selling Price (ASP) Trends by Type (2020-2031)
4.4 Product Technology Differentiation
4.5 Subtype Dynamics: Growth Leaders, Profitability and Risk
4.5.1 High-Growth Niches and Adoption Drivers
4.5.2 Profitability Hotspots and Cost Drivers
4.5.3 Substitution Threats
5 Global Downstream Application Analysis
5.1 Global Self-replicating mRNA Vaccines Sales by Application
5.1.1 Global Historical and Forecasted Sales by Application (2020-2031)
5.1.2 Global Sales Market Share by Application (2020-2031)
5.1.3 High-Growth Application Identification
5.1.4 Emerging Application Case Studies
5.2 Global Self-replicating mRNA Vaccines Revenue by Application
5.2.1 Global Historical and Forecasted Revenue by Application (2020-2031)
5.2.2 Revenue Market Share by Application (2020-2031)
5.3 Global Pricing Dynamics by Application (2020-2031)
5.4 Downstream Customer Analysis
5.4.1 Top Customers by Region
5.4.2 Top Customers by Application
6 North America
6.1 North America Sales Volume and Revenue (2020-2031)
6.2 North America Key Manufacturers Sales Revenue in 2024
6.3 North America Self-replicating mRNA Vaccines Sales and Revenue by Type (2020-2031)
6.4 North America Self-replicating mRNA Vaccines Sales and Revenue by Application (2020-2031)
6.5 North America Growth Accelerators and Market Barriers
6.6 North America Self-replicating mRNA Vaccines Market Size by Country
6.6.1 North America Revenue by Country
6.6.2 North America Sales Trends by Country
6.6.3 US
6.6.4 Canada
6.6.5 Mexico
7 Europe
7.1 Europe Sales Volume and Revenue (2020-2031)
7.2 Europe Key Manufacturers Sales Revenue in 2024
7.3 Europe Self-replicating mRNA Vaccines Sales and Revenue by Type (2020-2031)
7.4 Europe Self-replicating mRNA Vaccines Sales and Revenue by Application (2020-2031)
7.5 Europe Growth Accelerators and Market Barriers
7.6 Europe Self-replicating mRNA Vaccines Market Size by Country
7.6.1 Europe Revenue by Country
7.6.2 Europe Sales Trends by Country
7.6.3 Germany
7.6.4 France
7.6.5 U.K.
7.6.6 Italy
7.6.7 Russia
8 Asia-Pacific
8.1 Asia-Pacific Sales Volume and Revenue (2020-2031)
8.2 Asia-Pacific Key Manufacturers Sales Revenue in 2024
8.3 Asia-Pacific Self-replicating mRNA Vaccines Sales and Revenue by Type (2020-2031)
8.4 Asia-Pacific Self-replicating mRNA Vaccines Sales and Revenue by Application (2020-2031)
8.5 Asia-Pacific Self-replicating mRNA Vaccines Market Size by Region
8.5.1 Asia-Pacific Revenue by Region
8.5.2 Asia-Pacific Sales Trends by Region
8.6 Asia-Pacific Growth Accelerators and Market Barriers
8.7 Southeast Asia
8.7.1 Southeast Asia Revenue by Country (2020 VS 2024 VS 2031)
8.7.2 Key Country Analysis: Indonesia, Vietnam, Thailand, Malaysia, Philippines
8.8 China
8.9 Japan
8.10 South Korea
8.11 China Taiwan
8.12 India
9 Central and South America
9.1 Central and South America Sales Volume and Revenue (2020-2031)
9.2 Central and South America Key Manufacturers Sales Revenue in 2024
9.3 Central and South America Self-replicating mRNA Vaccines Sales and Revenue by Type (2020-2031)
9.4 Central and South America Self-replicating mRNA Vaccines Sales and Revenue by Application (2020-2031)
9.5 Central and South America Investment Opportunities and Key Challenges
9.6 Central and South America Self-replicating mRNA Vaccines Market Size by Country
9.6.1 Central and South America Revenue Trends by Country (2020 VS 2024 VS 2031)
9.6.2 Brazil
9.6.3 Argentina
10 Middle East and Africa
10.1 Middle East and Africa Sales Volume and Revenue (2020-2031)
10.2 Middle East and Africa Key Manufacturers Sales Revenue in 2024
10.3 Middle East and Africa Self-replicating mRNA Vaccines Sales and Revenue by Type (2020-2031)
10.4 Middle East and Africa Self-replicating mRNA Vaccines Sales and Revenue by Application (2020-2031)
10.5 Middle East and Africa Investment Opportunities and Key Challenges
10.6 Middle East and Africa Self-replicating mRNA Vaccines Market Size by Country
10.6.1 Middle East and Africa Revenue Trends by Country (2020 VS 2024 VS 2031)
10.6.2 GCC Countries
10.6.3 Turkey
10.6.4 Egypt
10.6.5 South Africa
11 Corporate Profile
11.1 Chimeron Bio
11.1.1 Chimeron Bio Corporation Information
11.1.2 Chimeron Bio Business Overview
11.1.3 Chimeron Bio Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.1.4 Chimeron Bio Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.1.5 Chimeron Bio Self-replicating mRNA Vaccines Sales by Product in 2024
11.1.6 Chimeron Bio Self-replicating mRNA Vaccines Sales by Application in 2024
11.1.7 Chimeron Bio Self-replicating mRNA Vaccines Sales by Geographic Area in 2024
11.1.8 Chimeron Bio Self-replicating mRNA Vaccines SWOT Analysis
11.1.9 Chimeron Bio Recent Developments
11.2 Ziphius Vaccines
11.2.1 Ziphius Vaccines Corporation Information
11.2.2 Ziphius Vaccines Business Overview
11.2.3 Ziphius Vaccines Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.2.4 Ziphius Vaccines Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.2.5 Ziphius Vaccines Self-replicating mRNA Vaccines Sales by Product in 2024
11.2.6 Ziphius Vaccines Self-replicating mRNA Vaccines Sales by Application in 2024
11.2.7 Ziphius Vaccines Self-replicating mRNA Vaccines Sales by Geographic Area in 2024
11.2.8 Ziphius Vaccines Self-replicating mRNA Vaccines SWOT Analysis
11.2.9 Ziphius Vaccines Recent Developments
11.3 Aldevron
11.3.1 Aldevron Corporation Information
11.3.2 Aldevron Business Overview
11.3.3 Aldevron Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.3.4 Aldevron Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.3.5 Aldevron Self-replicating mRNA Vaccines Sales by Product in 2024
11.3.6 Aldevron Self-replicating mRNA Vaccines Sales by Application in 2024
11.3.7 Aldevron Self-replicating mRNA Vaccines Sales by Geographic Area in 2024
11.3.8 Aldevron Self-replicating mRNA Vaccines SWOT Analysis
11.3.9 Aldevron Recent Developments
11.4 VaxEquity
11.4.1 VaxEquity Corporation Information
11.4.2 VaxEquity Business Overview
11.4.3 VaxEquity Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.4.4 VaxEquity Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.4.5 VaxEquity Self-replicating mRNA Vaccines Sales by Product in 2024
11.4.6 VaxEquity Self-replicating mRNA Vaccines Sales by Application in 2024
11.4.7 VaxEquity Self-replicating mRNA Vaccines Sales by Geographic Area in 2024
11.4.8 VaxEquity Self-replicating mRNA Vaccines SWOT Analysis
11.4.9 VaxEquity Recent Developments
11.5 Precision Nanosystems
11.5.1 Precision Nanosystems Corporation Information
11.5.2 Precision Nanosystems Business Overview
11.5.3 Precision Nanosystems Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.5.4 Precision Nanosystems Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.5.5 Precision Nanosystems Self-replicating mRNA Vaccines Sales by Product in 2024
11.5.6 Precision Nanosystems Self-replicating mRNA Vaccines Sales by Application in 2024
11.5.7 Precision Nanosystems Self-replicating mRNA Vaccines Sales by Geographic Area in 2024
11.5.8 Precision Nanosystems Self-replicating mRNA Vaccines SWOT Analysis
11.5.9 Precision Nanosystems Recent Developments
11.6 Replicate Bioscience
11.6.1 Replicate Bioscience Corporation Information
11.6.2 Replicate Bioscience Business Overview
11.6.3 Replicate Bioscience Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.6.4 Replicate Bioscience Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.6.5 Replicate Bioscience Recent Developments
11.7 Elixirgen Therapeutics
11.7.1 Elixirgen Therapeutics Corporation Information
11.7.2 Elixirgen Therapeutics Business Overview
11.7.3 Elixirgen Therapeutics Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.7.4 Elixirgen Therapeutics Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.7.5 Elixirgen Therapeutics Recent Developments
11.8 Immorna
11.8.1 Immorna Corporation Information
11.8.2 Immorna Business Overview
11.8.3 Immorna Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.8.4 Immorna Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.8.5 Immorna Recent Developments
11.9 CSL
11.9.1 CSL Corporation Information
11.9.2 CSL Business Overview
11.9.3 CSL Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.9.4 CSL Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.9.5 CSL Recent Developments
11.10 Arcturus Therapeutics
11.10.1 Arcturus Therapeutics Corporation Information
11.10.2 Arcturus Therapeutics Business Overview
11.10.3 Arcturus Therapeutics Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.10.4 Arcturus Therapeutics Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.10.5 Arcturus Therapeutics Recent Developments
11.11 BioNTech
11.11.1 BioNTech Corporation Information
11.11.2 BioNTech Business Overview
11.11.3 BioNTech Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.11.4 BioNTech Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.11.5 BioNTech Recent Developments
11.12 GSK
11.12.1 GSK Corporation Information
11.12.2 GSK Business Overview
11.12.3 GSK Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.12.4 GSK Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.12.5 GSK Recent Developments
11.13 Gritstone Bio
11.13.1 Gritstone Bio Corporation Information
11.13.2 Gritstone Bio Business Overview
11.13.3 Gritstone Bio Self-replicating mRNA Vaccines Product Models, Descriptions and Specifications
11.13.4 Gritstone Bio Self-replicating mRNA Vaccines Sales, Price, Revenue and Gross Margin (2020-2025)
11.13.5 Gritstone Bio Recent Developments
12 Value Chain and Supply-Chain Analysis
12.1 Self-replicating mRNA Vaccines Industry Chain
12.2 Self-replicating mRNA Vaccines Upstream Materials Analysis
12.2.1 Raw Materials
12.2.2 Key Suppliers Market Share & Risk Assessment
12.3 Self-replicating mRNA Vaccines Integrated Production Analysis
12.3.1 Manufacturing Footprint Analysis
12.3.2 Regional Production Market Share (2020-2031)
12.3.3 Regulatory and Trade Policy Impact on Production
12.3.4 Production Technology Overview
12.3.5 Regional Cost Drivers
12.4 Self-replicating mRNA Vaccines Sales Channels and Distribution Networks
12.4.1 Sales Channels
12.4.2 Distributors
13 Self-replicating mRNA Vaccines Market Dynamics
13.1 Industry Trends and Evolution
13.2 Market Growth Drivers and Emerging Opportunities
13.3 Market Challenges, Risks, and Restraints
14 Key Findings in the Global Self-replicating mRNA Vaccines Study
15 Appendix
15.1 Research Methodology
15.1.1 Methodology/Research Approach
15.1.1.1 Research Programs/Design
15.1.1.2 Market Size Estimation
15.1.1.3 Market Breakdown and Data Triangulation
15.1.2 Data Source
15.1.2.1 Secondary Sources
15.1.2.2 Primary Sources
15.2 Author Details
FEATURED COMPANIES
Chimeron Bio
Ziphius Vaccines
Aldevron
VaxEquity
Precision Nanosystems
Replicate Bioscience
Elixirgen Therapeutics
Immorna
CSL Limited
Arcturus Therapeutics
BioNTech
GSK
Gritstone Bio
List of Tables
 Table 1. Global Self-replicating mRNA Vaccines Market Size Growth Rate by Type, 2020 VS 2024 VS 2031 (US$ Million)
 Table 2. Global Self-replicating mRNA Vaccines Market Size Growth Rate by Application, 2020 VS 2024 VS 2031 (US$ Million)
 Table 3. Global Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Region: 2020 VS 2024 VS 2031 (US$ Million)
 Table 4. Global Self-replicating mRNA Vaccines Revenue by Region (2020-2025) & (US$ Million)
 Table 5. Global Self-replicating mRNA Vaccines Revenue by Region (2026-2031) & (US$ Million)
 Table 6. Global Self-replicating mRNA Vaccines Sales Grow Rate (CAGR) by Region: 2020 VS 2024 VS 2031 (K Units)
 Table 7. Global Self-replicating mRNA Vaccines Sales by Region (2020-2025) & (K Units)
 Table 8. Global Self-replicating mRNA Vaccines Sales by Region (2026-2031) & (K Units)
 Table 9. Emerging Market Revenue Grow Rate (CAGR) by Country (2020 VS 2024 VS 2031) (US$ Million)
 Table 10. Global Self-replicating mRNA Vaccines Sales by Manufacturers (2020-2025) & (K Units)
 Table 11. Global Self-replicating mRNA Vaccines Sales Share by Manufacturers (2020-2025)
 Table 12. Global Self-replicating mRNA Vaccines Revenue by Manufacturers (2020-2025) & (US$ Million)
 Table 13. Global Self-replicating mRNA Vaccines Revenue Market Share by Manufacturers (2020-2025)
 Table 14. Global Key Manufacturers’Ranking Shift (2023 vs. 2024) (Based on Revenue)
 Table 15. Global Self-replicating mRNA Vaccines by Manufacturer Tier (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in Self-replicating mRNA Vaccines as of 2024)
 Table 16. Global Self-replicating mRNA Vaccines Average Gross Margin (%) by Manufacturer (2020 VS 2024)
 Table 17. Global Self-replicating mRNA Vaccines Average Selling Price (ASP) by Manufacturers (2020-2025) & (US$/Unit)
 Table 18. Key Manufacturers Self-replicating mRNA Vaccines Manufacturing Base and Headquarters
 Table 19. Global Self-replicating mRNA Vaccines Market Concentration Ratio (CR5 and HHI)
 Table 20. Key Market Entrant/Exit (2020-2024) – Drivers & Impact Analysis
 Table 21. Key Mergers & Acquisitions, Expansion Plans, R&D Investment
 Table 22. Global Self-replicating mRNA Vaccines Sales by Type (2020-2025) & (K Units)
 Table 23. Global Self-replicating mRNA Vaccines Sales by Type (2026-2031) & (K Units)
 Table 24. Global Self-replicating mRNA Vaccines Revenue by Type (2020-2025) & (US$ Million)
 Table 25. Global Self-replicating mRNA Vaccines Revenue by Type (2026-2031) & (US$ Million)
 Table 26. Global Self-replicating mRNA Vaccines ASP by Type (2020-2031) & (US$/Unit)
 Table 27. Technical Specifications by Key Product Type
 Table 28. Global Self-replicating mRNA Vaccines Sales by Application (2020-2025) & (K Units)
 Table 29. Global Self-replicating mRNA Vaccines Sales by Application (2026-2031) & (K Units)
 Table 30. Self-replicating mRNA Vaccines High-Growth Sectors Demand CAGR (2024-2031)
 Table 31. Global Self-replicating mRNA Vaccines Revenue by Application (2020-2025) & (US$ Million)
 Table 32. Global Self-replicating mRNA Vaccines Revenue by Application (2026-2031) & (US$ Million)
 Table 33. Global Self-replicating mRNA Vaccines ASP by Application (2020-2031) & (US$/Unit)
 Table 34. Top Customers by Region
 Table 35. Top Customers by Application
 Table 36. North America Self-replicating mRNA Vaccines Growth Accelerators and Market Barriers
 Table 37. North America Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Country (2020 VS 2024 VS 2031) (US$ Million)
 Table 38. North America Self-replicating mRNA Vaccines Sales (K Units) by Country (2020 VS 2024 VS 2031)
 Table 39. Europe Self-replicating mRNA Vaccines Growth Accelerators and Market Barriers
 Table 40. Europe Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Country: 2020 VS 2024 VS 2031 (US$ Million)
 Table 41. Europe Self-replicating mRNA Vaccines Sales (K Units) by Country (2020 VS 2024 VS 2031)
 Table 42. Asia-Pacific Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Region: 2020 VS 2024 VS 2031 (US$ Million)
 Table 43. Asia-Pacific Self-replicating mRNA Vaccines Sales (K Units) by Country (2020 VS 2024 VS 2031)
 Table 44. Asia-Pacific Self-replicating mRNA Vaccines Growth Accelerators and Market Barriers
 Table 45. Southeast Asia Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Region: 2020 VS 2024 VS 2031 (US$ Million)
 Table 46. Central and South America Self-replicating mRNA Vaccines Investment Opportunities and Key Challenges
 Table 47. Central and South America Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Country (2020 VS 2024 VS 2031) (US$ Million)
 Table 48. Middle East and Africa Self-replicating mRNA Vaccines Investment Opportunities and Key Challenges
 Table 49. Middle East and Africa Self-replicating mRNA Vaccines Revenue Grow Rate (CAGR) by Country (2020 VS 2024 VS 2031) (US$ Million)
 Table 50. Chimeron Bio Corporation Information
 Table 51. Chimeron Bio Description and Major Businesses
 Table 52. Chimeron Bio Product Models, Descriptions and Specifications
 Table 53. Chimeron Bio Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 54. Chimeron Bio Sales Value Proportion by Product in 2024
 Table 55. Chimeron Bio Sales Value Proportion by Application in 2024
 Table 56. Chimeron Bio Sales Value Proportion by Geographic Area in 2024
 Table 57. Chimeron Bio Self-replicating mRNA Vaccines SWOT Analysis
 Table 58. Chimeron Bio Recent Developments
 Table 59. Ziphius Vaccines Corporation Information
 Table 60. Ziphius Vaccines Description and Major Businesses
 Table 61. Ziphius Vaccines Product Models, Descriptions and Specifications
 Table 62. Ziphius Vaccines Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 63. Ziphius Vaccines Sales Value Proportion by Product in 2024
 Table 64. Ziphius Vaccines Sales Value Proportion by Application in 2024
 Table 65. Ziphius Vaccines Sales Value Proportion by Geographic Area in 2024
 Table 66. Ziphius Vaccines Self-replicating mRNA Vaccines SWOT Analysis
 Table 67. Ziphius Vaccines Recent Developments
 Table 68. Aldevron Corporation Information
 Table 69. Aldevron Description and Major Businesses
 Table 70. Aldevron Product Models, Descriptions and Specifications
 Table 71. Aldevron Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 72. Aldevron Sales Value Proportion by Product in 2024
 Table 73. Aldevron Sales Value Proportion by Application in 2024
 Table 74. Aldevron Sales Value Proportion by Geographic Area in 2024
 Table 75. Aldevron Self-replicating mRNA Vaccines SWOT Analysis
 Table 76. Aldevron Recent Developments
 Table 77. VaxEquity Corporation Information
 Table 78. VaxEquity Description and Major Businesses
 Table 79. VaxEquity Product Models, Descriptions and Specifications
 Table 80. VaxEquity Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 81. VaxEquity Sales Value Proportion by Product in 2024
 Table 82. VaxEquity Sales Value Proportion by Application in 2024
 Table 83. VaxEquity Sales Value Proportion by Geographic Area in 2024
 Table 84. VaxEquity Self-replicating mRNA Vaccines SWOT Analysis
 Table 85. VaxEquity Recent Developments
 Table 86. Precision Nanosystems Corporation Information
 Table 87. Precision Nanosystems Description and Major Businesses
 Table 88. Precision Nanosystems Product Models, Descriptions and Specifications
 Table 89. Precision Nanosystems Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 90. Precision Nanosystems Sales Value Proportion by Product in 2024
 Table 91. Precision Nanosystems Sales Value Proportion by Application in 2024
 Table 92. Precision Nanosystems Sales Value Proportion by Geographic Area in 2024
 Table 93. Precision Nanosystems Self-replicating mRNA Vaccines SWOT Analysis
 Table 94. Precision Nanosystems Recent Developments
 Table 95. Replicate Bioscience Corporation Information
 Table 96. Replicate Bioscience Description and Major Businesses
 Table 97. Replicate Bioscience Product Models, Descriptions and Specifications
 Table 98. Replicate Bioscience Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 99. Replicate Bioscience Recent Developments
 Table 100. Elixirgen Therapeutics Corporation Information
 Table 101. Elixirgen Therapeutics Description and Major Businesses
 Table 102. Elixirgen Therapeutics Product Models, Descriptions and Specifications
 Table 103. Elixirgen Therapeutics Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 104. Elixirgen Therapeutics Recent Developments
 Table 105. Immorna Corporation Information
 Table 106. Immorna Description and Major Businesses
 Table 107. Immorna Product Models, Descriptions and Specifications
 Table 108. Immorna Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 109. Immorna Recent Developments
 Table 110. CSL Corporation Information
 Table 111. CSL Description and Major Businesses
 Table 112. CSL Product Models, Descriptions and Specifications
 Table 113. CSL Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 114. CSL Recent Developments
 Table 115. Arcturus Therapeutics Corporation Information
 Table 116. Arcturus Therapeutics Description and Major Businesses
 Table 117. Arcturus Therapeutics Product Models, Descriptions and Specifications
 Table 118. Arcturus Therapeutics Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 119. Arcturus Therapeutics Recent Developments
 Table 120. BioNTech Corporation Information
 Table 121. BioNTech Description and Major Businesses
 Table 122. BioNTech Product Models, Descriptions and Specifications
 Table 123. BioNTech Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 124. BioNTech Recent Developments
 Table 125. GSK Corporation Information
 Table 126. GSK Description and Major Businesses
 Table 127. GSK Product Models, Descriptions and Specifications
 Table 128. GSK Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 129. GSK Recent Developments
 Table 130. Gritstone Bio Corporation Information
 Table 131. Gritstone Bio Description and Major Businesses
 Table 132. Gritstone Bio Product Models, Descriptions and Specifications
 Table 133. Gritstone Bio Sales (K Units), Revenue (US$ Million), Price (US$/Unit) and Gross Margin (2020-2025)
 Table 134. Gritstone Bio Recent Developments
 Table 135. Key Raw Materials Distribution
 Table 136. Raw Materials Key Suppliers
 Table 137. Critical Raw Material Supplier Concentration (2024) & Risk Index
 Table 138. Milestones in Production Technology Evolution
 Table 139. Distributors List
 Table 140. Market Trends and Market Evolution
 Table 141. Market Drivers and Opportunities
 Table 142. Market Challenges, Risks, and Restraints
 Table 143. Research Programs/Design for This Report
 Table 144. Key Data Information from Secondary Sources
 Table 145. Key Data Information from Primary Sources


List of Figures
 Figure 1. Self-replicating mRNA Vaccines Product Picture
 Figure 2. Global Self-replicating mRNA Vaccines Market Size Growth Rate by Type, 2020 VS 2024 VS 2031 (US$ Million)
 Figure 3. Preventive Medicine Product Picture
 Figure 4. Medicine Product Picture
 Figure 5. Global Self-replicating mRNA Vaccines Market Size Growth Rate by Application, 2020 VS 2024 VS 2031 (US$ Million)
 Figure 6. Infectious Disease
 Figure 7. Cancer
 Figure 8. Others
 Figure 9. Self-replicating mRNA Vaccines Report Years Considered
 Figure 10. Global Self-replicating mRNA Vaccines Revenue, (US$ Million), 2020 VS 2024 VS 2031
 Figure 11. Global Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 12. Global Self-replicating mRNA Vaccines Revenue (CAGR) by Region: 2020 VS 2024 VS 2031 (US$ Million)
 Figure 13. Global Self-replicating mRNA Vaccines Revenue Market Share by Region (2020-2031)
 Figure 14. Global Self-replicating mRNA Vaccines Sales (2020-2031) & (K Units)
 Figure 15. Global Self-replicating mRNA Vaccines Sales (CAGR) by Region (2020-2031) (K Units)
 Figure 16. Global Self-replicating mRNA Vaccines Sales Market Share by Region (2020-2031)
 Figure 17. Top 5 and Top 10 Manufacturers Self-replicating mRNA Vaccines Sales Volume Market Share in 2024
 Figure 18. Global Self-replicating mRNA Vaccines Revenue Market Share Ranking (2024)
 Figure 19. Tier Distribution by Revenue Contribution (2020 VS 2024)
 Figure 20. Preventive Medicine Revenue Market Share by Manufacturer in 2024
 Figure 21. Medicine Revenue Market Share by Manufacturer in 2024
 Figure 22. Global Self-replicating mRNA Vaccines Sales Market Share by Type (2020-2031)
 Figure 23. Global Self-replicating mRNA Vaccines Revenue Market Share by Type (2020-2031)
 Figure 24. Global Self-replicating mRNA Vaccines Sales Market Share by Application (2020-2031)
 Figure 25. Global Self-replicating mRNA Vaccines Revenue Market Share by Application (2020-2031)
 Figure 26. North America Self-replicating mRNA Vaccines Sales YoY (2020-2031) & (K Units)
 Figure 27. North America Self-replicating mRNA Vaccines Revenue YoY (2020-2031) & (US$ Million)
 Figure 28. North America Top 5 Manufacturers Self-replicating mRNA Vaccines Sales Revenue (US$ Million) in 2024
 Figure 29. North America Self-replicating mRNA Vaccines Sales Volume (K Units) by Type (2020- 2031)
 Figure 30. North America Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Type (2020 - 2031)
 Figure 31. North America Self-replicating mRNA Vaccines Sales Volume (K Units) by Application (2020-2031)
 Figure 32. North America Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Application (2020-2031)
 Figure 33. US Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 34. Canada Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 35. Mexico Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 36. Europe Self-replicating mRNA Vaccines Sales YoY (2020-2031) & (K Units)
 Figure 37. Europe Self-replicating mRNA Vaccines Revenue YoY (2020-2031) & (US$ Million)
 Figure 38. Europe Top 5 Manufacturers Self-replicating mRNA Vaccines Sales Revenue (US$ Million) in 2024
 Figure 39. Europe Self-replicating mRNA Vaccines Sales Volume (K Units) by Type (2020-2031)
 Figure 40. Europe Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Type (2020-2031)
 Figure 41. Europe Self-replicating mRNA Vaccines Sales Volume (K Units) by Application (2020-2031)
 Figure 42. Europe Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Application (2020-2031)
 Figure 43. Germany Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 44. France Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 45. U.K. Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 46. Italy Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 47. Russia Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 48. Asia-Pacific Self-replicating mRNA Vaccines Sales YoY (2020-2031) & (K Units)
 Figure 49. Asia-Pacific Self-replicating mRNA Vaccines Revenue YoY (2020-2031) & (US$ Million)
 Figure 50. Asia-Pacific Top 8 Manufacturers Self-replicating mRNA Vaccines Sales Revenue (US$ Million) in 2024
 Figure 51. Asia-Pacific Self-replicating mRNA Vaccines Sales Volume (K Units) by Type (2020- 2031)
 Figure 52. Asia-Pacific Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Type (2020- 2031)
 Figure 53. Asia-Pacific Self-replicating mRNA Vaccines Sales Volume (K Units) by Application (2020-2031)
 Figure 54. Asia-Pacific Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Application (2020-2031)
 Figure 55. Indonesia Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 56. Japan Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 57. South Korea Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 58. China Taiwan Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 59. India Self-replicating mRNA Vaccines Revenue (2020-2031) & (US$ Million)
 Figure 60. Central and South America Self-replicating mRNA Vaccines Sales YoY (2020-2031) & (K Units)
 Figure 61. Central and South America Self-replicating mRNA Vaccines Revenue YoY (2020-2031) & (US$ Million)
 Figure 62. Central and South America Top 5 Manufacturers Self-replicating mRNA Vaccines Sales Revenue (US$ Million) in 2024
 Figure 63. Central and South America Self-replicating mRNA Vaccines Sales Volume (K Units) by Type (2021-2031)
 Figure 64. Central and South America Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Type (2020-2031)
 Figure 65. Central and South America Self-replicating mRNA Vaccines Sales Volume (K Units) by Application (2020-2031)
 Figure 66. Central and South America Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Application (2020-2031)
 Figure 67. Brazil Self-replicating mRNA Vaccines Revenue (2020-2025) & (US$ Million)
 Figure 68. Argentina Self-replicating mRNA Vaccines Revenue (2020-2025) & (US$ Million)
 Figure 69. Middle East, and Africa Self-replicating mRNA Vaccines Sales YoY (2020-2031) & (K Units)
 Figure 70. Middle East and Africa Self-replicating mRNA Vaccines Revenue YoY (2020-2031) & (US$ Million)
 Figure 71. Middle East and Africa Top 5 Manufacturers Self-replicating mRNA Vaccines Sales Revenue (US$ Million) in 2024
 Figure 72. Middle East and Africa Self-replicating mRNA Vaccines Sales Volume (K Units) by Type (2021-2031)
 Figure 73. South America Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Type (2020-2031)
 Figure 74. Middle East and Africa Self-replicating mRNA Vaccines Sales Volume (K Units) by Application (2020-2031)
 Figure 75. Middle East and Africa Self-replicating mRNA Vaccines Sales Revenue (US$ Million) by Application (2020-2031)
 Figure 76. GCC Countries Self-replicating mRNA Vaccines Revenue (2020-2025) & (US$ Million)
 Figure 77. Turkey Self-replicating mRNA Vaccines Revenue (2020-2025) & (US$ Million)
 Figure 78. Egypt Self-replicating mRNA Vaccines Revenue (2020-2025) & (US$ Million)
 Figure 79. South Africa Self-replicating mRNA Vaccines Revenue (2020-2025) & (US$ Million)
 Figure 80. Self-replicating mRNA Vaccines Industry Chain Mapping
 Figure 81. Regional Self-replicating mRNA Vaccines Manufacturing Base Distribution (%)
 Figure 82. Global Self-replicating mRNA Vaccines Production Market Share by Region (2020-2031)
 Figure 83. Self-replicating mRNA Vaccines Production Process
 Figure 84. Regional Self-replicating mRNA Vaccines Production Cost Structure
 Figure 85. Channels of Distribution (Direct Vs Distribution)
 Figure 86. Bottom-up and Top-down Approaches for This Report
 Figure 87. Data Triangulation
 Figure 88. Key Executives Interviewed
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